CCL2 and ischemia: Silencing of MALAT1 led to the increase in pro-apoptotic factor Bim and expression of pro-inflammatory cytokines monocyte chemotactic protein-1 (MCP-1), interleukin 6 (IL-6), and E-selectin in brain microvascular endothelial cells (BMECs), as well as in ischemia insulted mice brain81.