The EGFR‐FASN link, however, is absent in TKI‐sensitive EGFR mutant (PC‐9P and HCC4006P) and EGFR wild‐type (H1703) NSCLC cells, indicating that the novel molecular link we herein report is confined to Gefitinib‐resistant NSCLC cells with EGFR mutant status, and independent of EGFR T790M mutation. Here, FASN is linked to non-small cell lung carcinoma.