Further, since palmitoylation has been shown to modulate protein stability by blocking its ubiquitination (Valdez‐Taubas & Pelham, 2005; Kong et al, 2013), we wondered whether a link between palmitoylation and degradation of EGFR may be observed in TKI‐resistant NSCLC cells. This evidence concerns the gene EGFR and non-small cell lung carcinoma.