Orlistat, an anti‐obesity drug which targets FASN via its thioesterase domain, has shown to possess anti‐proliferative properties and induces apoptosis in tumor cells derived from various malignancies (Pizer et al, 1996; Pemble et al, 2007; Carvalho et al, 2008; Zecchin et al, 2011). The gene discussed is FASN; the disease is neoplasm.