For example, a dominant association with ZFP36L2 in DNA replication-defective S-phase-arrested cells was identified for the BTB/POZ-Kelch domain protein IVNS1ABP, its binding protein PRPSAP1/2, cell cycle-linked KH domain protein hnRNP-K, and cytoplasmic RNA-binding protein SYNCRIP, whereas increased binding in nocodazole-arrested M-phase cells was observed for several proteins including the ALS-causative RNA-binding protein hnRNP-A2B1 and phospho-specific adaptor protein YWHAH (14-3-3η). This evidence concerns the gene HNRNPA2B1 and amyotrophic lateral sclerosis.