ZFP36L2 and colorectal cancer: In addition, we confirmed that ZFP36L2 protein fluctuated during the cell cycle, not only in HeLa cells (Fig. 1A,D,E) but also in the near-diploid human colorectal cancer cell line HCT116 (Fig. 1G; Fig. S1B), by greatly down-regulating its protein level at the post-mitotic stages.