To confirm that anxA1-mediated induction of TGF-β was an extracellular event, likely dependent on activation of the formyl-peptide receptor type 2, mice undergoing zymosan-induced peritonitis were injected intraperitoneally with 2 × 107 neutrophil MVs (pooled from 6 donors) with or without the selective FPR2 antagonist WRW4. Here, ANXA1 is linked to peritonitis.