As shown in Fig. 4, wild type mice given ConA present with significant increases in a number of inflammatory mediators associated with acute hepatitis including tumor necrosis factor alpha (TNFγ; Fig. 4a), certain Th1 type cytokines including interferon gamma (IFNγ; Fig. 4b), and interleukin 12 (IL12; Fig. 4c) and certain Th2 type cytokines including interleukin 4 (IL4; Fig. 4d) interleukin 5 (IL5; Fig. 4e), and interleukin 10 (IL10; Fig. 4f). The gene discussed is TNF; the disease is Acute hepatitis.