TP53 and head and neck squamous cell carcinoma: Among them, the gene most commonly mutated is TP53: 96% in ovarian serous carcinoma [7], 85% in small cell lung cancer [5], 75% in pancreatic cancer [8], 60% in head and neck squamous cell carcinoma [9], 54% in invasive breast carcinoma [10], just to mention few tumor types.