Moreover, by examining histological sections of tumor biopsies collected from patients prior to receiving immunotherapy, three basic immune profiles that correlate with response to anti-PD-L1/PD-1 therapy have been described, namely an immune-inflamed phenotype generally correlated with higher response rates to anti-PD-L1/PD-1 therapy, an immune-excluded phenotype associated with uncommon clinical responses, and an immune-desert phenotype rarely responsive to anti-PD-L1/PD-1 therapy [21]. Here, CD274 is linked to neoplasm.