Another novel CAR that exerts a TCR-like function to bind the acute myeloid leukemia (AML)-specific PR1/HLA-A2 complex has been recently developed to efficiently and rapidly kill AML cells in vitro, broadening the application of CAR-T cell therapy especially for those solid tumors with presentation of neoantigens in an HLA-dependent manner [88–94]. The gene discussed is TMEM37; the disease is acute myeloid leukemia.