CHI3L1 levels also correlated with markers of immune activation (CRP, sTREM-1, CXCL10/IP-10), endothelial activation (Ang-2, sICAM-1), and haemolysis (LDH, haem, haemopexin), pathways of injury that are well described in paediatric severe malaria [26–28, 46–48]. This evidence concerns the gene CHI3L1 and malaria.