APP and Alzheimer disease: For instance, circRNA ciRS-7, containing more than 70 conserved miRNA target sites, can sponge miR-7 and thus depress the expression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) gene, leading to degrade the protein levels of β-amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 (BACE1), suggesting that ciRS-7 may represent a useful target in the development of therapeutic strategies for AD [6,10].