EDN1 and hypertensive disorder: A reduced concentrationof NO due to decreased expression of eNOS has previously been reported in thepathological states of hypertension [54] and LVH [19].There are a number of possible causes for the reduced NO concentration, includingreduced NO elaboration from eNOS, increased oxidative inactivation of NO andincreased production of vasoconstrictors like endothelin-1 and thromboxane A2 [55, 56].