Interestingly, we found overexpression of TRIM44 in RBE cells could also up‐regulate phosphorylation of MEK and phosphorylation of ERK1/2 (Fig. 5A, and Fig. S3A), both of which belong to the MAPK pathway and is always aberrantly elevated in human cancers 26, 27. This evidence concerns the gene MAP2K7 and cancer.