2006). However, it seems that the biological function of adiponectin is undermined in an obesity context, where a negative effect of over nutrition has been described on the action of this protein in terms of promoting fat utilization for energy production (Krause et al. 2008; Ritchie and Dyck 2012). Interestingly, Yang et al. (2006) found major decreases (50%) in adiponectin content in rat gastrocnemius after 20 weeks of high‐fat/high‐sucrose diet, arising questions about the relevance of the animal model chosen to study these changes. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.