Furthermore, a differential response between the two exercise programs was observed, where END induced a further increase in muscle HMW adiponectin, a change that was associated with the prevention of hyperglycemia, hyperinsulinemia and dysregulation of the AST/ALT ratio in high‐fat fed animals that underwent this type of training, which was not seen after HIIT exercise training. The gene discussed is ADIPOQ; the disease is Hyperglycemia.