Furthermore, this model displayed the expected lung pathologies such as peribronchiolar inflammation, neutrophil infiltration and increased mucus production.41 These HIS mice displayed lower levels of infection over NSG controls with increased levels of human IL‐1β and CCL‐3.41 Furthermore, the human IgA production in the sera was elevated and RSV epitope‐specific CD8+ splenocytes were isolated following infection and capable of producing IFN‐γ. This evidence concerns the gene CD8A and infection.