Adenovirus infection in humanized mice has recently been reported to mimic both the adenovirus acute and latent phases of infection.86 Humanized NSG‐A2 mice demonstrate asymptomatic infection in 66% of infected mice, yielding only the expression of E1A, which can be detected throughout major organs within humanized mice including lymph nodes, spleen and bone marrow.86 Asymptomatic, latent phase infection produces a productive CD8+ antigen‐specific T‐cell response and are able to produce IFN‐γ upon ex vivo stimulation.86 This evidence concerns the gene CD8A and infection.