After adjustment for multiple testing, this study showed statistically significant interactions between rs1056827 in CYP1B1, rs2959008 and rs7173655 in CYP11A1, the deletion of GSTT1, and rs1052133 in hOGG1 and acrylamide intake for ER+ breast cancer risk. The gene discussed is CYP11A1; the disease is breast carcinoma.