AKR1C1 and breast carcinoma: However, it is of interest that some of the genes that we observed to interact with acrylamide for ER+ breast cancer risk or that showed clear differences in risk between the genotypes also did so for endometrial [7] and ovarian cancer [8]: GSTT1, AKR1C1, NQO1, the HSD3B1/B2 gene cluster, XPC, and MGC12965. These genes therefore deserve attention in future studies.