This axis regulates cell growth and cell polarity, two essential features that guarantee proper differentiation of neural stem cells, through combined action of the conserved PI3K/AKT and aPKC/Lgl pathways [115]. Drosophila is routinely used as a model for the study of cancer biology [33], so we investigated the consequences of alterations in these pathways on different neural progenitors found in the Drosophila brain. The gene discussed is AKT1; the disease is cancer.