Moreover, the nonpsychotic dementia group and AD group showed slight publication biases and had the following Egger's test values: for insulin, t = 3.26, d.f. = 50, and P = 0.001 (Additional File 9); and for AD, t = 2.399, d.f. = 32, and P = 0.011 (Additional File10). The gene discussed is INS; the disease is Alzheimer disease.