This clinical question (CQ) offers recommendations regarding the validity of the three biomarkers, PCT, P‐SEP, and IL‐6 to support the diagnosis of sepsis in two clinical settings: (i) settings with critically‐ill patients, such as in ICUs, where infection is suspected but difficult to confirm, and (ii) settings in which infection is suspected but patients are not critically ill such as the emergency room or general ward. Here, IL6 is linked to infection.