SOAT1 and RASopathy: Concerning molecular diagnosis, it has been shown that activating mutations in the MAPK pathway leading to nuclear factor kappa beta (NFκβ) overactivation inhibits the Janus kinase (JAK)/STAT pathway 11, 19, in what was classically considered “rasopathies.” STAT5b is the most important transcription factor for IGF‐1 13.