IGF1 and hyperinsulinemic hypoglycemia, familial, 4: Never‐treated IGF‐1‐deficient patients (i.e., from IGF‐1 deficiency conditions like GHI, fetal growth restriction, polycystic ovarian syndrome, and hepatic cirrhosis) may also develop metabolic problems leading to metabolic syndrome and ultimately to type 2 diabetes 8, 16, 17, 18.