IRS1 and 3-M syndrome: Typically, Cullin‐7 is associated with the so‐called 3‐M syndrome, being a E3 ubiquitin ligase at the proteasome in charge, among others, in the turnover and splicing of GHR and several growth factors receptors (including IGF1R) and, more importantly, in the degradation of IRS1, crucial for IGF‐1 receptor signaling 21.