This includes known epigenetic silenced repair genes like MGMT, MLH1, and ERCC1 but also novel targets of epigenetic dysregulation like RBBP8/CtiP, which has a proven role in homologous recombination-mediated DNA double-strand break repair and is further known to sensitize cancer cells for PARP1 inhibitors. Here, RBBP8 is linked to cancer.