The synergistic nature of curcumin with vitamin D in regulating immune cells provides an opportunity for researchers to improve the response of vitamin D3 therapy, improve clinical symptoms, decrease disease progression, and reduce mortality rates in SLE patients with hypovitamin D by combining curcumin supplementation with vitamin D. Curcumin supplementation on vitamin D3 administration may affect the balance of TGF-β1/IL-6 cytokines at cellular level. This evidence concerns the gene TGFB1 and systemic lupus erythematosus.