A notable finding was that in metabolically normal individuals, SVR was related to insulin response after oral glucose challenge independent of BMI, VAT, and MetS components, and those with higher SVR had better insulin secretory capacity of β-cell (demonstrated as right shifted hyperbolas of I0–30/G0–30 and I30–120/G30–120 versus Matsuda index), indicating that higher subcutaneous with lower visceral fat accumulation would exert beneficial effect on β-cell function in the prevailing insulin sensitivity status. This evidence concerns the gene INS and metabolic syndrome.