SLC39A13 and Schnyder corneal dystrophy: In contrast, Jeong et al. based on their cellular localization of ZIP13 to the vesicular compartment, claimed that ZIP13 might function to release labile zinc from vesicular stores for use in the ER and other compartments (Jeong et al., 2012), and proposed that ZIP13 loss of function could lead to general ER dysfunction and thus explained the biochemical findings of SCD–EDS (Figure 2; Jeong et al., 2012).