In the current study, we investigated 12 serum proteins related to inflammation (CRP and SAA), endothelium activation and adhesion (sICAM1 and sVCAM1), immune and cellular activation (sTNFR1, sTNFR2, sIL2Rα, sgp130, and sIL6R), and ECM modeling enzymes (MMP1, MMP2, and MMP9) in T1D patients with and without MA. The gene discussed is IL6R; the disease is type 1 diabetes mellitus.