The elevated serum levels of inflammatory, matrix metalloproteinase, and endothelial markers observed in this study reflect an increase in TNF-α and IL6-mediated secondary inflammation and endothelial dysfunction which may result in abnormal changes in renal physiology, integrity, and retention and migration of leukocytes in the kidneys of T1D patients. The gene discussed is IL6; the disease is type 1 diabetes mellitus.