CD8A and graft versus host disease: We finally assessed the suppressive potential of expanded CD8+CD45RClow/− Tregs using two distinct models of human immune responses in NSG (NOD-Scid-IL-2Rγ-/-) mice, rejection of human skin grafts following injection of allogeneic human PBMCs (Figure 5A; Figure S6A in Supplementary Material) and xenogeneic GVHD following injection of human PBMCs (Figure 5B).