NFE2L2 and cancer: The nuclear factor erythroid-related factor 2 (Nrf2) is a transcription factor that plays a significant role in protection against oxidative stress to maintain intrinsic redox homeostasis, and numerous studies suggest that the cellular protection provided by an abnormal expression of Nrf2 confers cancer cells a proliferation advantage and the ability to resist antitumor drugs (Samatiwat et al., 2016; Bai et al., 2017; Roh et al., 2017).