GABR alteration may be related to the clinical presentation of movement disorders: for instance, increased expression of GABRα4 has been described in tremor rats (Mao et al., 2011), and our own findings suggest that the GABRA4 rs2229940 T/T genotype is related to younger age at onset of restless legs syndrome (Jiménez-Jiménez et al. submitted). This evidence concerns the gene GABRA4 and restless legs syndrome.