Indeed, the association between SNP genotypes of the LXRα gene and the late age of onset was validated by this study, as was the fact that the C/C of SNP genotype rs2695121 from the LXRβ gene is associated with a 30% increase in ALS survival (Mouzat et al., 2017). This evidence concerns the gene NR1H3 and amyotrophic lateral sclerosis.