CASC8 and cancer: Positive association was also found between intronic variants in the cancer susceptibility 8 (CASC8) gene on chromosome 8q24 and TA for SNP rs10505477 genotypes and alleles (P = 8.16 × 10−5 and P = 1.7 × 10−5, respectively) and rs7014346 (P = 0.0005 for genotype under a recessive model) (Table 2).