As consequence, the aims of the study were: (i) to examine the plasma vs. saliva correlation level of cytokines; (ii) to examine the changes in salivary and plasmatic concentration of the CRP, IL-1β, IL-18, IL-6, and also of the anxiety and anger expression in undergraduate male students on a Resting Day (RD), and in response to a socio-cognitive stressor (Academic Examination, AE). The gene discussed is IL18; the disease is Anxiety.