Depletion of LysM+ cells early after DVT induction (see Fig. 2A) preferentially deletes the more pro-inflammatory CD11b+Gr-1+ cells comprising both Ly6G+ neutrophils and Ly6Chi monocytes which are a prime source of IL-12, thereby allowing the reparative Gr-1− monocytes to invade and clear the clot. Here, ITGAM is linked to deep vein thrombosis.