AKT1 and hepatocellular carcinoma: HCC has been previously associated with the PI3K/Akt signaling pathway22, and CCR10 has been previously shown to drive PI3K/Akt pathway activation in response to ligand binding17.Thus, we investigated the effects of CCR10 upregulation on cell proliferation and PI3K/Akt pathway activation through transfection of a CCR10 plasmid into HepG2 and LO2 cell lines.