CHUK and cancer: We next examined the effects of small molecule inhibitors of the proteasome (bortezomib26), of IKKβ (IMD-035427), or of heat shock protein 90 (HSP90) (17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG)28) that display significant inhibitory activity against IKKβ and/or IKKα (of note, a specific IKKα inhibitor does not exist) on NF-κB reporter activity and cellular proliferation of our murine cancer cell lines (Fig. 1g, h; Supplementary Table 1).