In line with the above, Il1r1 (encoding IL1R1, cognate to IL-1α/β) expression, but not Tnfrsf1a/Tnfrsf1b (encoding TNF receptors) or Il1a/Il1b expression (that was undetectable in all cell lines), was exclusively restricted to KRASMUT MPE-proficient tumor cells (Fig. 2c, d). The gene discussed is IL1R1; the disease is neoplasm.