ACKR2 and neoplasm: At 25 weeks of age, NeuT/Ackr2−/− mice presented a further significant increase of blood monocytes and neutrophils (Fig. 2a, b) compared to Ackr2−/− and NeuT/Ackr2+/+, indicating that the lack of ACKR2 was a further driver of tumor-induced myelopoiesis and/or BM release of myeloid cells.