Multiple cytokines with adaptive immunomodulatory roles, including IL-1b, IFN-γ, monocyte chemotactic protein 1 (MCP-1), macrophage migration inhibitory factor (MIF), macrophage inflammatory protein 1b (MIP-1b), IL-8, and IFN-gamma-inducible protein 10 (IP-10), were concurrently elevated upon either ZIKV infection or ChinZIKV immunization. The gene discussed is IFNG; the disease is Zika virus infectious disease.