We could demonstrate that let-7c directly targets the genes EZH2 and DVL3. ShRNA mediated knockdown of DVL3 or EZH2 showed that only knockdown of expression of DVL3 promoted the pro-invasive activity of in vivo tail vein injected cholangiocarcinoma cells similar to let-7c overexpression. The gene discussed is DVL3; the disease is cholangiocarcinoma.