We found that ISL1 binds to an evolutionary conserved region within the first intron of Lmo1 (chr7:116289070-116289656) in mouse sympathetic neurons that overlaps with the super-enhancer of LMO1 identified in human neuroblastoma, suggesting co-regulation of LMO1 expression by ISL1 and GATA3 and a potential role of ISL1 in controlling neuroblastoma cell proliferation. The gene discussed is LMO1; the disease is neuroblastoma.