Notably, a number of targets of ISL1 downregulated in Isl1 CKO mutants were implicated in neuroblastoma pathogenesis20–23, including Lmo1, Gata3, Prox1, Lin28b, and Alk. We found that ISL1 binds to an evolutionary conserved region within the first intron of Lmo1 (mm9:chr7:116289070-116289656) in mouse sympathetic neurons that, by whole-genome alignment, overlaps with the super-enhancer of LMO1 identified in human neuroblastoma20. Here, ALK is linked to neuroblastoma.