CCND1 and neuroblastoma: We found that a number of genes implicated in neuroblastoma pathogenesis are downstream of ISL1 (e.g., Lmo1, Ccnd1, Tfap2b, Prox1, Casz1, Foxm1, Lin28b, Ccnd1, and Alk)20–23,34,36–38, many of which are direct targets of ISL1.