We found that a number of genes implicated in neuroblastoma pathogenesis are downstream of ISL1 (e.g., Lmo1, Ccnd1, Tfap2b, Prox1, Casz1, Foxm1, Lin28b, Ccnd1, and Alk)20–23,34,36–38, many of which are direct targets of ISL1. Here, LIN28B is linked to neuroblastoma.