Three such SGLT2 inhibitors, canagliflozin (Invokana®), dapagliflozin (Forxiga®) and empagliflozin (Jardiance®), are currently approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for treatment of T2DM. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.