Compared with the high expression of CALML3 in THLE-3, CALML3 was significantly downregulated in most hepatoma cell lines, especially in cells (MHCC97L, MHCC97H and HCCLM3) with relatively high metastatic potential, and moderately expressed in hepatoma cells (HepG2, SMMC-7721 and PLC/PRF/5) with low metastatic potential (Fig. 3b). Here, CALML3 is linked to hepatocellular carcinoma.