CALML3 and neoplasm: In addition, to further verify the role of CALML3 as a tumour suppressor, we overexpressed CALML3 in HCCLM3 cells with high metastatic potential and decreased CALML3 expression in HepG2 cells with low metastatic potential by lentiviral-mediated expression and RNA interference, respectively (Supplementary Fig. 4a).