To further understand the underlying roles of DNB genes in metastasis initiation for primary tumour cells, we ranked comprehensively the DNB genes according to the criteria with four priorities, i.e., importance in the networks, importance in functional pathways, differential patterns, and dynamic patterns (see Ranking scheme for DNB members in Methods), and selected CALML3 as the top one for further functional study (Fig. 3a, Supplementary Data 2). Here, CALML3 is linked to neoplasm.