CALML3 and neoplasm: Moreover, CALML3 expression was significantly lower in the tumour tissues of pulmonary metastatic group (average score, 1.94 ± 2.19; 86%, 86/100) than that of non-pulmonary metastatic group (average score, 4.96 ± 3.08; 41.1%, 70/170) (Fig. 6c, d), indicating that loss of CALML3 was a risk factor of pulmonary metastasis of HCC.