Pathway-based approaches and functional experimental studies have been adopted in identifying the dysfunction of different signalling cascades in HCC metastasis (e.g., insulin-like growth factor (IGF), mitogen-activated protein kinase (MAPK), phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR), and WNT/β-catenin)10 and disease-related biomarkers. This evidence concerns the gene MTOR and hepatocellular carcinoma.