PRICKLE4 and age-related macular degeneration: Among the DE anti-sense transcripts, matrix remodeling associated 8 (MXRA8), prickle planar cell polarity protein 4 (PRICKLE4) and many solute carrier family proteins among other protein coding genes were identified, which appear to be significantly downregulated at least 3 to 4-fold in AMD retina as compared to the normal.