The predominant anti-sense transcripts that appeared significantly downregulated (≥3 fold, q-value ≥ 1E-12) in AMD PRCS as compared to normal include RBP5, MST1, MYL5 and LCAT among other lincRNA, indicating that anti-sense transcription is highly varied in both retina and PRCS tissues during age-related macular degeneration. This evidence concerns the gene RBP5 and age-related macular degeneration.