Furthermore, AKT2-siRNA partially suppressed FGF21-induced beneficial effects against cell hypertrophy, fibrosis, and apoptosis induced by HG/Pal, implying that AKT2–NRF2-induced antioxidative pathway partially mediated the cardiac protection of FGF21 against DCM. Here, FGF21 is linked to familial dilated cardiomyopathy.