SHC1 and Alzheimer disease: Figure 3 demonstrates linear associations with the eleven candidates and shows that plasma levels of ABCC11, TNFRSF10D, F11R and ERRF were positively associated with AD, while SHC1, CFLAR, ACOX2, ITGB6, RASSF1, FANCD2 and IRX5 were negatively associated with AD.