Both the RAS pathway related protein SHC1, which transmits signalling of cell surface receptors to activate downstream pathways, and the homeobox protein IRX5, involved in cell differentiation and cell cycle regulation, were negatively associated with AD, ss was the acyl-coenzyme A oxidase ACOX2, part of the degradation of long branched fatty acids. The gene discussed is POU2F2; the disease is Alzheimer disease.