CASP3 and early-onset autosomal dominant Alzheimer disease: In line with our findings, Jhamandas and co-workers [54] showed neuroprotective activity of a fucoidan sulfated polysaccharide, isolated from the brown seaweed Fucus vesiculosus, through the ability to protect neuronal death in rats treated with Aβ1–42 the by inhibition of Caspase-3 in an Alzheimer’s disease model.