Thirty children aged 3-17 years with allergic asthma and IgE > 600 IU/ml measured by IMMULITE 2000 XPi system (Siemens, Germany), sensitized to house dust mites and molds were included in a 2-year cohort study of the efficacy and safety of SLIT (Diater Laboratories, Spain) using standardized sublingual extracts containing house dust mites or molds (Alternaria alternata). This evidence concerns the gene IGHE and allergic asthma.