In order to determine the global and confirm the deferential cytokine profile of CD4+CCR4+CD7- cells in patients with non-malignant HTLV-1 infection and ATL, we studied the expression of cytokines, chemokines and their receptors by mRNA sequencing of sorted CD4+CCR4+CD7- T cells in eight patients with non-malignant (four AC and four patients with HAM) and eight with ATL. This evidence concerns the gene CCR4 and tropical spastic paraparesis.