SUCNR1 and metabolic dysfunction-associated steatotic liver disease: Regarding the role of succinate in the liver, recent study reported that activated GPR91 led to stimulation of HSCs and using adeno -associated virus (AAV) -mediated RNA disruption of GPR91 gene expression in MCD diet -fed mice as a model of non -alcoholic fatty liver disease (NAFLD), considerably ameliorated steatohepatitis and fibrosis [14].