WNK2 and escherichia coli infection: Among the down-regulated gene sets, we detected genes belonging to a wide range of pathways involved in nucleotide-binding oligomerization domain-like (NOD-like) receptor signaling, pathogenic Escherichia coli infection, purine and pyrimidine metabolism, extracellular matrix (ECM) receptor interaction associated with the mutual communications between the leukocytes-extracellular matrix, mitogen-activated protein kinase (MAPK) and mechanistic target of rapamycin (MTOR) signaling pathways, and apoptosis.