Genomic alterations in KRT8 were present in 83 cases, ranging from 0 to 11% (mean 1.9%) of cases by cancer type, with the highest prevalence of KRT8 genomic alterations observed in adrenocortical carcinoma (11.4%), stomach adenocarcinoma (4.9%), and uterine endometrial carcinoma (4.1%). The gene discussed is KRT8; the disease is cancer.