Elevated KRT8 expression is important for ATC tumor cell survival, since, as demonstrated in this study, siRNA-mediated knockdown of KRT8 expression results in increased apoptosis and loss of cell viability in ATC-derived cells in vitro; conversely, expression of KRT8 in normally low-expressing ATC cells confers resistance to apoptosis under conditions of redox stress. Here, KRT8 is linked to neoplasm.