SYCP1 and central nervous system cancer: The possible connection between gametogenesis and cancer development has been previously suggested; for example, the expression of the synaptonemal complex protein 1 (SCP1), a protein selectively expressed during the meiotic prophase of the spermatocyte, has been reported in several tumour types, including: glioma, breast cancer, and melanoma, suggesting that it may contribute to genomic instability [59].