HAMP and anemia (phenotype): Therefore, hepcidin and iron storage work in a control feedback system by which the elevation of iron regulates the synthesis of hepcidin [46]; while a decrease in the concentrations of this mineral (e.g., anemia) promotes a reduction in hepcidin production, facilitating iron absorption from the diet and reutilization from hemolysis, and increasing erythropoiesis and iron reserves [47].